The R498 road, linking Nenagh with Thurles, has been closed this morning between Ballinamona Cross south of Nenagh and Fantane, north of Borrisoleigh village.
The closure has been caused by an accidental fuel spill and the emergency services are currently dealing with the problem.
Motorists are being asked to take extreme care while driving in the area, and to follow diversion signs in place, thus avoiding the area.
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